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THE SCIENCE
BEHIND THE TEST

A Pharmacogenomic, a.k.a PGx, genetic test evaluates an individual’s DNA to determine how they metabolize or respond to medications. Pharmacogenomic testing may help improve clarity regarding drug selection as these tests analyze clinically important genetic variations in an individual’s DNA. This information can be used by healthcare providers to better predict which medications may require dose adjustments, may be less likely to work, or may have an increased risk of side effects based on a patient’s genetic makeup.

Genetic Test for Medication Metabolism

What is Pharmacogenomic Testing?

Pharmacogenomic tests – also called PGx tests – is a genetic test that looks at your unique DNA to determine how your body is likely to process the medications you take. Each of us processes medications based on a number of factors, and our genes are especially important.

What genes does Verdosome analyze?

ABCB1, APOE, COMT, CYP1A2, CYP2B6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, CYP3A5, DRD2, F2, F5, GLP1R, MTHFR, OPRM1, SLCO1B1, SULT4A1, VKORC1, PNPLA5

What does my DNA have to do with my medication?

Your genes can affect how quickly your body breaks down – or metabolizes – medicine and how certain medicines work inside you. No two people have identical genetic profiles (unless they’re identical twins, and even identical twins will have some minor variation between them).

There are more than 20,000 genes in your body, but when it comes to processing medications, one of the most important places to look is in a set of about 50 genes called Cytochrome P450, or CYP 450 for short. These genes are responsible for producing the enzymes that metabolize literally thousands of medications. In fact, according to American Family Physician, there are 6 genes in particular that produce enzymes which metabolize about 90 percent of all the medications you’re likely to take. 

What sort of results can I expect to see? 

Research has found that people metabolize different medications at different rates. Based on your genetic profile, you may be a poor metabolizer for one enzyme, but an extensive metabolizer for another. There are four different metabolizer types:

Poor metabolizer

You may break down some medications much more slowly than normal. As a result, the medication may build up in your system, which may produce unwanted – and potentially dangerous – side effects. You may also not get the therapeutic benefit expected from the medication. 

Intermediate metabolizer

You process some medications more slowly than normal. This could lead to a buildup of the medication in your system, which could lead to dangerous side effects while also producing less-than-expected therapeutic benefits.

Extensive (normal) metabolizer

You have a normal rate of metabolism. You are predicted to have a normal amount of medication at standard doses.

Ultrarapid metabolizer

You may break down some medications more quickly than normal. As a result, you may not have enough medication in your system to generate the expected activity.

HOW IT WORKS

What should I do with the information I learn?

PGx testing may help give you and your physician important information to create a care plan built around your particular physiology. Healthcare providers can evaluate the medications and dosages you’re taking now to determine if adjustments may be worth considering, and they can use this same information to evaluate medications you may take in the future. Knowing your expected drug response can help your doctor identify those drugs that may be more or less likely to have a therapeutic benefit for you and which may have an increased risk of potentially dangerous side effects. 

Physician Guidance PGx Testing

1. Request a consultation

Fill out our consultation request form. It takes just a couple of minutes, and when you’re done, we’ll contact you to determine your genetic testing options. Medicare and Medicaid beneficiaries may be eligible for testing with no out-of-pocket costs.

Collect PGx Saliva Sample

2. Collect and send

Once approved, you will receive your testing kit. It takes just minutes to produce a sample with our easy-to-use saliva test kit – all with absolutely no discomfort. Ship your sample to the lab with the pre-paid, pre-addressed label included with your test kit.

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3. Receive your results

Our state-of-the-art equipment processes your sample and reports drug metabolism and health predispositions based on 20 critical genes. Receive your complete, easy-to-read report, including guidance for your physician to help you develop a medication management and treatment plan.

Are your medications doing what they’re supposed to? 

Patients who have experienced the frustration of, “the trial-and-error process” tend to lose confidence in their health care providers, ultimately giving up on possible solutions to help them feel better. If you have experienced this you know what it is like to miss out on normal life events likes birthdays, family events, relationships etc. – time you can never get back. The insight provided by Verdosome’s genetic test is for informational purposes only and does not constitute medical advice. Do not make any changes to your current medications or dosing without consulting your doctor.